Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529292 | 0.88 | DPP4 (0.66) | DPP4DPP8DPP7CYP1A2POLB | |
| SCHEMBL6529428 | 0.88 | DPP4 (0.66) | DPP4DPP8DPP7CYP1A2POLB | |
| SCHEMBL6531352 | 0.81 | DPP4 (0.45) | DPP4DPP8DPP7 | |
| SCHEMBL6528970 | 0.79 | DPP4 (0.79) | DPP4DPP8DPP7 | |
| SCHEMBL6527845 | 0.79 | DPP4 (0.61) | DPP4DPP8DPP7GPR119POLB | |
| SCHEMBL6530127 | 0.79 | DPP4 (0.56) | DPP4DPP8DPP7GPR119CYP1A2 | |
| SCHEMBL6532393 | 0.74 | DPP4 (0.61) | DPP4DPP8DPP7CYP1A2POLB | |
| SCHEMBL6530249 | 0.74 | DPP4 (0.61) | DPP4DPP8DPP7CYP1A2POLB | |
| SCHEMBL1334717 | 0.73 | NR1H2 (0.39) | DPP4CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL641763 | 0.73 | HSD17B10 (0.42) | DPP4CYP1A2POLBCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037828-A1 | NOVEL INHIBITORS OF DPP-IV, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT | LG LIFE SCIENCES LTD. (KR) | 2005-04-28 | — | — | WO | disclosed |