Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532662 | 0.88 | CTSK (0.42) | CTSKALDH1A1MAPTHPGD | |
| SCHEMBL6531457 | 0.88 | ATM (0.45) | CTSKALDH1A1HPGD | |
| SCHEMBL6530873 | 0.86 | MAPT (0.41) | KMT2ACTSKALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL6528931 | 0.85 | KCNH3 (0.41) | KMT2ACTSKALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL6508189 | 0.85 | KCNH3 (0.41) | KMT2ACTSKALDH1A1MEN1MAPK1 | |
| SCHEMBL6528847 | 0.85 | SYK (0.43) | KMT2ACTSKALDH1A1MEN1 | |
| SCHEMBL6508192 | 0.85 | KCNH3 (0.41) | KMT2ACTSKALDH1A1MEN1MAPK1 | |
| SCHEMBL6530634 | 0.85 | CTSK (0.45) | CTSKALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6528746 | 0.83 | CTSK (0.44) | KMT2ACTSKMEN1 | |
| SCHEMBL6528788 | 0.83 | CTSK (0.43) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | claimed |
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |