SCHEMBL6529797

SCHEMBL6529797

CCCCC(C)(C)C(=O)Oc1cccs1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 2/20 0.42
HDAC3 O15379 1/20 0.38
MMP1 P03956 1/20 0.38
MMP2 P08253 1/20 0.38
MMP9 P14780 1/20 0.38
MMP12 P39900 1/20 0.38
RIPK1 Q13546 1/20 0.37
HDAC1 Q13547 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
PLA2G1B P04054 1/20 0.36
KMT2A Q03164 1/20 0.36
ATG4B Q9Y4P1 1/20 0.36
TSHR P16473 3/20 0.36
ALDH1A1 P00352 3/20 0.36
HTT P42858 2/20 0.35
MAPT P10636 2/20 0.35
CTSK P43235 1/20 0.34
GLA P06280 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27756838 0.84 RIPK1 (0.47) ELANEMMP1MMP2MMP9MMP12
SCHEMBL27362639 0.77 ELANE (0.46) ELANEMMP1MMP2MMP9MMP12
SCHEMBL16552524 0.75 KMT2A (0.49) HDAC3MMP1MMP2MMP9MMP12
SCHEMBL7202273 0.75 ELANE (0.58) ELANEL3MBTL1
SCHEMBL1228081 0.75 MMP1 (0.38) HDAC3MMP1MMP2MMP9MMP12
SCHEMBL28962592 0.75 MMP1 (0.38) MMP1MMP2MMP9MMP12RIPK1
SCHEMBL6859151 0.74 MMP1 (0.45) HDAC3MMP1MMP2MMP9MMP12
SCHEMBL30543 0.74 KMT2A (0.44) HDAC3MMP1MMP2MMP9MMP12
SCHEMBL11305274 0.74 ELANE (0.56) ELANEL3MBTL1
SCHEMBL1756481 0.73 POLM (0.46) HDAC1HDAC11HDAC8HDAC6KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005047236-A1 SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS, INC. (US) 2005-05-26 WO disclosed
US-6673780-B2 SUCH AS 4-(4-(3-HYDROXY-3-METHYL-BUTANE-1-SULFINYLMETHYL)-PHENYLMETHANESULFINYL)-2 -METHYL-BUTAN1-OL FOR TREATING AND PREVENTING CARDIOVASCULAR DISEASES, DYSLIPIDEMIAS, DYSPROTEINEMIAS, AND GLUCOSE METABOLISM DISORDERS ESPERION THERAPEUTICS, INC. 2004-01-06 US disclosed
EP-1366024-A2 SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES Esperion Therapeutics Inc. (US) 2003-12-03 EP disclosed
WO-2002030882-A9 SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS INC (US) 2003-02-20 WO disclosed
WO-2002030882-A2 SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES ESPERION THERAPEUTICS, INC. (US) 2002-04-18 WO disclosed