Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.59 |
| ▸ | MMP9 | P14780 | 16/20 | 0.59 |
| ▸ | MMP1 | P03956 | 13/20 | 0.59 |
| ▸ | ADAM10 | O14672 | 7/20 | 0.59 |
| ▸ | MMP14 | P50281 | 6/20 | 0.59 |
| ▸ | MMP2 | P08253 | 6/20 | 0.59 |
| ▸ | MMP13 | P45452 | 10/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.57 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.57 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | ADAM8 | P78325 | 4/20 | 0.55 |
| ▸ | MMP12 | P39900 | 3/20 | 0.55 |
| ▸ | MMP7 | P09237 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | BMP1 | P13497 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944147 | 1.00 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3940147 | 0.97 | ADAM17 (0.58) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL7421462 | 0.92 | ADAM17 (0.61) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3947078 | 0.92 | ADAM17 (0.61) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3949062 | 0.92 | ADAM17 (0.60) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL7425442 | 0.91 | ADAM17 (0.68) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3944287 | 0.91 | ADAM17 (0.68) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL7423135 | 0.90 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3944138 | 0.90 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 | |
| SCHEMBL3940926 | 0.90 | ADAM17 (0.59) | ADAM17MMP9MMP1ADAM10MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | WYETH HOLDINGS CORPORATION | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, MMP12 | ADAM17 30/4885MMP9 161/4885MMP1 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.