SCHEMBL6530570

SCHEMBL6530570

COC(=S)NCc1cn(-c2cc(F)c(C3=CCN(C(=O)C4COC(C)(C)O4)CC3)c(F)c2)nn1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GRM1 Q13255 9/20 0.34
GRM5 P41594 7/20 0.34
NOTUM Q6P988 1/20 0.32
CCNT1 O60563 2/20 0.31
CDK9 P50750 2/20 0.31
GPR119 Q8TDV5 1/20 0.30
MIF P14174 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6527389 0.84 NOTUM (0.34) NOTUMMIF
SCHEMBL6532166 0.82 GRM1 (0.32) GRM1GRM5
SCHEMBL6532170 0.82 BTK (0.33) GRM1GRM5
SCHEMBL6528492 0.81 GRM1 (0.37) GRM1GRM5MIF
SCHEMBL6531659 0.81 GRM1 (0.54) GRM1GRM5CDK9GPR119
SCHEMBL6529331 0.80 GRM1 (0.38) GRM1GRM5NOTUMGPR119MIF
SCHEMBL6534143 0.77 GRM1 (0.42) GRM1GRM5NOTUMCCNT1CDK9
SCHEMBL6530571 0.76 CCNT1 (0.32) CCNT1CDK9
SCHEMBL6530409 0.76 GRM1 (0.54) GRM1GRM5CDK9GPR119
SCHEMBL6924641 0.73 KDM1A (0.35) NOTUMMIF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082892-A2 TRIAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S LABORATORIES LTD. (IN) 2005-09-09 WO disclosed