Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28372184 | 0.84 | TDP1 (0.65) | TDP1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL13485778 | 0.84 | TDP1 (0.65) | TDP1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL38664746 | 0.82 | TDP1 (0.62) | TDP1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL1411297 | 0.82 | TDP1 (0.62) | TDP1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL7199438 | 0.82 | ATM (0.65) | TDP1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL11419959 | 0.82 | TDP1 (0.62) | TDP1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL3167336 | 0.79 | TDP1 (0.69) | TDP1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL14520097 | 0.79 | MEN1 (0.66) | TDP1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL10079871 | 0.79 | ALDH1A1 (0.72) | TDP1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL1947868 | 0.79 | ALDH1A1 (0.68) | TDP1KMT2AMEN1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |