Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5408788 | 0.78 | TP53 (0.48) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL5861219 | 0.76 | IDO1 (0.43) | MEN1KMT2AALDH1A1MAPTDHFR | |
| SCHEMBL17262275 | 0.75 | MAOA (0.50) | MEN1KMT2AALDH1A1MAPTDHFR | |
| SCHEMBL7662525 | 0.73 | HAO1 (0.46) | MEN1KMT2AALDH1A1MAPTHAO1 | |
| SCHEMBL9044636 | 0.72 | KMT2A (0.51) | MEN1KMT2AMAPTHTT | |
| SCHEMBL9150436 | 0.72 | DHFR (0.60) | KMT2ADHFRRXFP1EGFRTYMS | |
| SCHEMBL30548759 | 0.72 | MEN1 (0.62) | MEN1KMT2AALDH1A1MAPTDHFR | |
| SCHEMBL11392611 | 0.70 | HAO1 (0.46) | MEN1KMT2AALDH1A1MAPTDHFR | |
| SCHEMBL829981 | 0.69 | AURKA (0.48) | MEN1KMT2AALDH1A1MAPTDHFR | |
| SCHEMBL4692835 | 0.69 | MAPT (0.45) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003103-A2 | 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |