Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 9/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | TYMS | P04818 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9145080 | 0.79 | RXFP1 (0.71) | DHFREGFRTYMSRXFP1KMT2A | |
| SCHEMBL19363998 | 0.76 | P2RX3 (0.60) | DHFR | |
| SCHEMBL19407644 | 0.76 | DHFR (0.50) | DHFR | |
| SCHEMBL13842554 | 0.72 | P2RX3 (0.63) | DHFRKMT2A | |
| SCHEMBL30488020 | 0.72 | KMT2A (0.73) | DHFRKMT2A | |
| SCHEMBL264291 | 0.72 | KMT2A (0.73) | DHFRKMT2A | |
| SCHEMBL6532226 | 0.72 | MEN1 (0.44) | DHFREGFRTYMSPDGFRBRXFP1 | |
| SCHEMBL30548759 | 0.72 | MEN1 (0.62) | DHFREGFRTYMSPDGFRBKMT2A | |
| SCHEMBL8964803 | 0.71 | MEN1 (0.54) | DHFREGFRTYMSPDGFRBKMT2A | |
| SCHEMBL17097395 | 0.71 | SMN1; SMN2 (0.54) | DHFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674627-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014780-A1 | PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |