Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 4/20 | 0.84 |
| ▸ | MMP2 | P08253 | 5/20 | 0.78 |
| ▸ | MMP9 | P14780 | 5/20 | 0.78 |
| ▸ | MMP8 | P22894 | 5/20 | 0.78 |
| ▸ | MMP13 | P45452 | 5/20 | 0.78 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820125 | 0.92 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6281518 | 0.92 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL2242293 | 0.88 | MMP2 (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6259448 | 0.86 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202512 | 0.86 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL3917809 | 0.86 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202550 | 0.86 | HPSE (0.88) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6506260 | 0.84 | MMP2 (0.93) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL2617477 | 0.83 | NPC1 (0.66) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL15157862 | 0.83 | HPSE (0.83) | HPSEMMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042496-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-BENZYL-AMINE DERIVATIVES AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |