Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.36 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532598 | 0.78 | P2RX7 (0.46) | P2RX7GAAALDH1A1LMNAHTT | |
| SCHEMBL28748312 | 0.78 | P2RX7 (0.46) | P2RX7GAAALDH1A1LMNAHTT | |
| SCHEMBL6527814 | 0.76 | KDR (0.35) | GAAALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL6532211 | 0.75 | HRH3 (0.36) | ALDH1A1LMNAHTT | |
| SCHEMBL6337183 | 0.74 | P2RX7 (0.58) | P2RX7GAAALDH1A1LMNAHTT | |
| SCHEMBL6337181 | 0.74 | P2RX7 (0.58) | P2RX7GAAALDH1A1LMNAHTT | |
| SCHEMBL6489296 | 0.71 | ALDH1A1 (0.36) | GAAALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL6500688 | 0.69 | P2RX7 (0.42) | P2RX7GAAALDH1A1LMNAHTT | |
| SCHEMBL6332688 | 0.69 | P2RX7 (0.55) | P2RX7GAAALDH1A1LMNAHTT | |
| SCHEMBL6340428 | 0.69 | P2RX7 (0.55) | P2RX7GAAALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | CYP3A5, IL5, ABCC5 | P2RX7 32/4885GAA 1394/4885ALDH1A1 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.