Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531817 | 0.76 | ALDH1A1 (0.44) | ALDH1A1MAPTSMN1; SMN2GAAKMT2A | |
| SCHEMBL6342770 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL6342765 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL6334608 | 0.74 | LMNA (0.42) | ALDH1A1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL6532607 | 0.71 | P2RX7 (0.43) | ALDH1A1MAPTSMN1; SMN2GAALMNA | |
| SCHEMBL6532211 | 0.68 | HRH3 (0.36) | ALDH1A1LMNAHTT | |
| SCHEMBL6343148 | 0.65 | ALDH1A1 (0.52) | ALDH1A1POLBGAALMNAKMT2A | |
| SCHEMBL6496972 | 0.65 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL6496976 | 0.65 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL6487979 | 0.64 | POLB (0.36) | ALDH1A1MAPTSMN1; SMN2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | CYP3A5, IL5, ABCC5 | ALDH1A1 187/4885MAPT 2904/4885SMN1; SMN2 3028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.