Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6390234 | 0.85 | HTR1A (0.43) | LMNAHTR1AHTR7HRH1DRD3 | |
| SCHEMBL6387778 | 0.82 | LMNA (0.43) | LMNAHTR1AHTR7HRH1DRD3 | |
| SCHEMBL6473079 | 0.80 | CYP1A2 (0.45) | LMNAHTR1AHTR7HRH1DRD3 | |
| SCHEMBL21069711 | 0.78 | HPGD (0.46) | LMNAHTR1AHTR7HRH1DRD3 | |
| SCHEMBL6471077 | 0.76 | MEN1 (0.33) | — | |
| SCHEMBL31419834 | 0.76 | CYP1A2 (0.53) | LMNAHTR1AHTR7HRH1DRD3 | |
| SCHEMBL20548002 | 0.73 | CYP1A2 (0.47) | LMNAHTR1AHTR7HRH1DRD3 | |
| SCHEMBL20547967 | 0.73 | CYP1A2 (0.47) | LMNAHTR1AHTR7HRH1DRD3 | |
| SCHEMBL29929381 | 0.73 | CYP1A2 (0.47) | LMNAHTR1AHTR7HRH1DRD3 | |
| SCHEMBL28910814 | 0.73 | CYP1A2 (0.47) | LMNAHTR1AHTR7HRH1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005068420-A1 | UREA AND THIOUREA COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2005-07-28 | — | — | WO | disclosed |