Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326515 | 0.82 | TSHR (0.48) | TSHRHTTALDH1A1NPSR1LMNA | |
| SCHEMBL6533164 | 0.77 | LMNA (0.41) | TSHRALDH1A1LMNAMAPTGAA | |
| SCHEMBL6533604 | 0.68 | RXRA (0.35) | TSHRRXRANR4A2ALDH1A1MAPK1 | |
| SCHEMBL4548475 | 0.66 | HCAR2 (0.64) | HCAR2 | |
| SCHEMBL6472555 | 0.66 | ACACB (0.61) | TSHRNPSR1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10312550 | 0.66 | HCAR2 (0.51) | TSHRRXRANR4A2ALDH1A1NPSR1 | |
| SCHEMBL11625598 | 0.62 | NOTUM (0.55) | TSHRHTTALDH1A1NPSR1MAPK1 | |
| SCHEMBL6334783 | 0.62 | RXRA (0.40) | HTTRXRANR4A2NPSR1LMNA | |
| Potassium Ion SCHEMBL11628009 | 0.61 | NOTUM (0.54) | TSHRHTTALDH1A1NPSR1MAPK1 | |
| Hydrochloric Acid SCHEMBL11626256 | 0.61 | TSHR (0.49) | TSHRHTTALDH1A1NPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |