Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NPPA | P01160 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325563 | 0.83 | MITF (0.51) | KMT2ATSHRALDH1A1MAPK1MAPT | |
| SCHEMBL6533607 | 0.80 | EPHX2 (0.35) | TSHREPHX2PPARA | |
| SCHEMBL6533162 | 0.68 | TSHR (0.36) | RXRANR4A2KMT2ATSHRALDH1A1 | |
| SCHEMBL6333227 | 0.68 | ALDH1A1 (0.54) | TSHRALDH1A1MAPK1MAPTMITF | |
| SCHEMBL6472555 | 0.66 | ACACB (0.61) | KMT2ATSHRSMN1; SMN2MITFTP53 | |
| SCHEMBL6323359 | 0.65 | HPGD (0.43) | KMT2AALDH1A1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL10312550 | 0.63 | HCAR2 (0.51) | RXRANR4A2TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL4548475 | 0.63 | HCAR2 (0.64) | — | |
| SCHEMBL11625598 | 0.62 | NOTUM (0.55) | KMT2ATSHRALDH1A1MAPK1MAPT | |
| SCHEMBL27589997 | 0.62 | MCL1 (0.50) | TSHRALDH1A1MAPTSMN1; SMN2MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |