Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | PRKCG | P05129 | 2/20 | 0.36 |
| ▸ | PRKCB | P05771 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 6/20 | 0.35 |
| ▸ | CNR2 | P34972 | 6/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10735488 | 0.64 | KMT2A (0.50) | HTR6SNCA | |
| SCHEMBL13437585 | 0.63 | HDAC3 (0.46) | HDAC3HTR6GSK3BPRKCBCNR1 | |
| SCHEMBL27220819 | 0.62 | ALDH1A1 (0.51) | MAOB | |
| SCHEMBL4974601 | 0.60 | HDAC3 (0.61) | HDAC3DRD3MAOBHDAC1HDAC2 | |
| SCHEMBL11795941 | 0.60 | HDAC3 (0.56) | HDAC3CNR2DRD3MAOBHDAC1 | |
| SCHEMBL13437554 | 0.60 | SMN1; SMN2 (0.50) | HTR6GSK3BPRKCBCNR1CNR2 | |
| SCHEMBL20754343 | 0.59 | HTT (0.61) | DRD3 | |
| SCHEMBL9417672 | 0.59 | GSK3B (0.44) | HDAC3HTR6GSK3BPRKCGPRKCB | |
| SCHEMBL11673147 | 0.59 | HDAC3 (0.62) | HDAC3DRD3MAOBHDAC1HDAC2 | |
| SCHEMBL24821329 | 0.58 | HDAC1 (0.42) | HDAC3HTR6HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509522-A1 | 1-(AMINOALKYL)-3-SULFONYLAZAINDOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth, A Corporation of the State of Delaware (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003101990-A1 | 1-(AMINOALKYL)-3-SULFONYLAZAINDOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2003-12-11 | — | — | WO | disclosed |