Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.46 |
| ▸ | WNT1 | P04628 | 5/20 | 0.46 |
| ▸ | FLT3 | P36888 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5945648 | 0.81 | FLT3 (0.50) | CSNK2A1DYRK1AWNT1FLT3CDK2 | |
| SCHEMBL5945720 | 0.79 | CDK2 (0.71) | CSNK2A1DYRK1AWNT1FLT3CDK2 | |
| SCHEMBL5945808 | 0.78 | FLT3 (0.70) | CSNK2A1DYRK1AFLT3CDK2GSK3B | |
| SCHEMBL4520668 | 0.78 | FLT3 (0.55) | CSNK2A1DYRK1AWNT1FLT3CDK2 | |
| SCHEMBL19001429 | 0.75 | YTHDC1 (0.63) | DYRK1AFLT3CDK2CCNA2CCNA1 | |
| SCHEMBL5945641 | 0.75 | FLT3 (0.48) | CSNK2A1DYRK1AWNT1FLT3CDK2 | |
| SCHEMBL5945662 | 0.74 | CSNK2A1 (0.76) | CSNK2A1DYRK1AWNT1FLT3CDK2 | |
| SCHEMBL5945670 | 0.71 | DYRK1A (0.65) | DYRK1AWNT1FLT3CDK2CLK2 | |
| SCHEMBL4521580 | 0.70 | DYRK1A (0.52) | CSNK2A1DYRK1AWNT1FLT3CDK2 | |
| SCHEMBL5525195 | 0.69 | SMN1; SMN2 (0.53) | DYRK1AWNT1GSK3BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014554-A1 | 1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS MAPKAP KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |