Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28821080 | 0.80 | KMT2A (0.51) | MAP2K1CREBBPKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2896747 | 0.79 | CREBBP (0.52) | CREBBPKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL9704727 | 0.79 | KMT2A (0.56) | KMT2AALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL29435808 | 0.77 | MAP2K1 (0.46) | MAP2K1MAP2K2KMT2A | |
| SCHEMBL6533268 | 0.77 | LMNA (0.48) | MAP2K1MAP2K2CREBBPKMT2AMEN1 | |
| SCHEMBL28821084 | 0.76 | CREBBP (0.47) | CREBBPKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL13702366 | 0.74 | BRD4 (0.54) | CREBBPKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL13702157 | 0.73 | CREBBP (0.50) | CREBBPKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL15224261 | 0.73 | CREBBP (0.50) | CREBBPKMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL22479631 | 0.73 | CREBBP (0.52) | MAP2K1MAP2K2CREBBPKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000818-A1 | 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-06 | — | — | WO | disclosed |