Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15224261 | 0.83 | CREBBP (0.50) | LMNACREBBPHTTHPGDL3MBTL1 | |
| SCHEMBL2896747 | 0.80 | CREBBP (0.52) | LMNACREBBPHTTHPGDL3MBTL1 | |
| SCHEMBL2736608 | 0.78 | ALDH1A1 (0.59) | LMNACREBBPHPGDPOLBBRD4 | |
| SCHEMBL13702366 | 0.78 | BRD4 (0.54) | LMNACREBBPHTTHPGDL3MBTL1 | |
| SCHEMBL6534016 | 0.77 | MAP2K1 (0.47) | LMNACREBBPHTTHPGDL3MBTL1 | |
| SCHEMBL620074 | 0.76 | POLB (0.66) | LMNAMMP13HTTHPGDPOLB | |
| SCHEMBL22479631 | 0.76 | CREBBP (0.52) | LMNACREBBPHTTHPGDL3MBTL1 | |
| SCHEMBL1309562 | 0.75 | EPHX2 (0.43) | HTTHPGDPOLBBRD4KMT2A | |
| SCHEMBL15245139 | 0.74 | BRD4 (0.44) | LMNAMMP13HTTHPGDPOLB | |
| SCHEMBL13702157 | 0.73 | CREBBP (0.50) | LMNACREBBPHTTHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000818-A1 | 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-06 | — | — | WO | disclosed |