Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 1/20 | 0.34 |
| ▸ | PTAFR | P25105 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23258136 | 0.78 | KIF11 (0.50) | KIF11XDHKMT2AALDH1A1KDM4E | |
| SCHEMBL16013364 | 0.71 | ALDH1A1 (0.44) | ALDH1A1KDM4ERAB9ANPC1POLB | |
| SCHEMBL18653354 | 0.71 | HTR2C (0.35) | KMT2AALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL29262131 | 0.71 | KIF11 (0.41) | KIF11KMT2AALDH1A1KDM4EDHODH | |
| SCHEMBL14602201 | 0.69 | AHR (0.61) | KIF11AKR1C2AKR1C1XDHCNR1 | |
| SCHEMBL16780836 | 0.69 | SLC6A2 (0.53) | ALDH1A1KDM4ERAB9ANPC1DHODH | |
| SCHEMBL15253926 | 0.68 | RAB9A (0.46) | KMT2AALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL19318451 | 0.68 | DHODH (0.48) | KIF11AKR1C2AKR1C1KMT2AALDH1A1 | |
| SCHEMBL10765944 | 0.68 | IDO1 (0.46) | ALDH1A1KDM4ERAB9ANPC1HPGD | |
| SCHEMBL18653355 | 0.68 | HTR2C (0.32) | ALDH1A1RAB9ANPC1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542692-A1 | AMINO-PYRIDINE, -PYRIDINE AND PYRIDAZINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN | Amgen Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2003099284-A1 | AMINO-PYRIDINE, -PYRIDINE AND PYRIDAZINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN | AMGEN INC. (US) | 2003-12-04 | — | — | WO | disclosed |