SCHEMBL6534525

SCHEMBL6534525

COc1cccc2c(=O)cc(-c3ccccc3)[nH]c12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 3/20 0.60
CYP1A2 P05177 3/20 0.60
CYP1B1 Q16678 3/20 0.60
GLA P06280 1/20 0.57
GAA P10253 1/20 0.57
HPGD P15428 4/20 0.55
ALDH1A1 P00352 3/20 0.55
KDM4E B2RXH2 3/20 0.54
TUBB4A P04350 3/20 0.54
TUBB P07437 3/20 0.54
TUBA3C P0DPH7 3/20 0.54
TUBA1B P68363 3/20 0.54
TUBA4A P68366 3/20 0.54
TUBB4B P68371 3/20 0.54
TUBB3 Q13509 3/20 0.54
TUBB2A Q13885 3/20 0.54
TUBB8 Q3ZCM7 3/20 0.54
TUBA3E Q6PEY2 3/20 0.54
TUBA1A Q71U36 3/20 0.54
TUBA1C Q9BQE3 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL909732 0.87 CYP1A1 (0.56) CYP1A1CYP1A2CYP1B1GLAGAA
SCHEMBL20605619 0.78 GAA (0.62) CYP1A1CYP1A2CYP1B1GLAGAA
SCHEMBL11665192 0.78 ITK (0.57) HPGDALDH1A1KDM4ETUBB4ATUBB
SCHEMBL30462937 0.78 HPGD (0.76) HPGDALDH1A1KDM4ETUBB4ATUBB
SCHEMBL9447439 0.78 TNKS (0.79) CYP1A1CYP1A2CYP1B1HPGDALDH1A1
SCHEMBL9974636 0.77 LMNA (0.62) CYP1A2HPGDALDH1A1KDM4ETUBB4A
SCHEMBL30054313 0.77 GAA (0.77) CYP1A2GLAGAAHPGDALDH1A1
SCHEMBL909804 0.76 ADORA2A (0.48) CYP1A1CYP1A2CYP1B1HPGDALDH1A1
SCHEMBL9254946 0.76 GLA (0.45) CYP1A1CYP1A2CYP1B1GLAGAA
SCHEMBL6143821 0.75 KDM4E (0.46) HPGDALDH1A1KDM4ETUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1088818-B1 Quinolin-4-yl derivatives HOFFMANN LA ROCHE (CH) 2004-11-03 EP disclosed
US-6440995-B1 NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS HOFFMAN-LA ROCHE INC. 2002-08-27 US disclosed
EP-1088818-A1 Quinolin-4-yl derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-04-04 EP disclosed