Leucine Amide

Leucine Amide

SCHEMBL6534879

CC(C)C[C@H](N)C(N)=O.O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)c1ccccc1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 1/20 0.58
CA2 P00918 4/20 0.56
CA1 P00915 3/20 0.56
CTSL P07711 1/20 0.55
ACE P12821 5/20 0.54
PSMB5 P28074 2/20 0.51
PTPN1 P18031 1/20 0.51
ERAP2 Q6P179 1/20 0.49
ERAP1 Q9NZ08 1/20 0.49
LNPEP Q9UIQ6 1/20 0.49
NPY1R P25929 1/20 0.49
NPY2R P49146 1/20 0.49
NPY4R P50391 1/20 0.49
CA12 O43570 1/20 0.49
CA9 Q16790 1/20 0.49
ITGB3 P05106 1/20 0.49
ITGA2B P08514 1/20 0.49
HPGDS O60760 1/20 0.49
LTA4H P09960 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetyl Tyrosine SCHEMBL7560091 0.86 FOLH1 (0.63) FOLH1ACENPY1RNPY2RNPY4R
Acetyl Tyrosine SCHEMBL7560086 0.86 FOLH1 (0.63) FOLH1ACENPY1RNPY2RNPY4R
Tyrosine SCHEMBL27889055 0.85 CA2 (0.64) CA2CA1CTSLACEPTPN1
SCHEMBL8667639 0.84 CA2 (0.69) FOLH1CA2CA1CTSLACE
SCHEMBL5793343 0.84 CA2 (0.69) FOLH1CA2CA1CTSLACE
SCHEMBL3404637 0.84 CA2 (0.69) FOLH1CA2CA1CTSLACE
Leucine SCHEMBL15689579 0.83 PSMB5 (0.57) CA2CA1CTSLACEPSMB5
Alcohol SCHEMBL19231109 0.82 CTSL (0.65) FOLH1CA2CA1CTSLACE
SCHEMBL11425335 0.82 HPGDS (0.68) CA2CA1CTSLACEPTPN1
SCHEMBL11781402 0.82 HPGDS (0.68) CA2CA1CTSLACEPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828847-A4 ENZYME CATALYSIS IN ORGANIC SOLUTIONS BIOTECHNOLOGY RES & DEV (US) 2004-12-08 EP disclosed
US-6171813-B1 MIXING CATALYST OF ENZYME-SURFACTANT ION PAIR COMPLEX WITH ORGANIC REACTION SOLVENT INCLUDING WATER FROM 0.03 TO 2.5% V/V; WATER INCREASES RATE OF CATALYSIS AND STABILIZES ENZYME WITHOUT INCREASING RATE OF HYDROLYSIS; PEPTIDE SYNTHESIS BIOTECHNOLOGY RESEARCH & DEVELOP. CORP. 2001-01-09 US disclosed
EP-0828847-A1 ENZYME CATALYSIS IN ORGANIC SOLUTIONS BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION (US) 1998-03-18 EP disclosed
US-5719039-A FOR PEPTIDE SYNTHESIS FROM ACYL DONORS AND NUCLEOPHILES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1998-02-17 US disclosed
WO-1996038577-A1 ENZYME CATALYSIS IN ORGANIC SOLUTIONS BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORP. (US) 1996-12-05 WO disclosed