SCHEMBL6535128

SCHEMBL6535128

CCOCCC(SC(CCOCC)c1ccccc1O)c1ccccc1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.44
GABRA1 P14867 1/20 0.40
GABRB2 P47870 1/20 0.40
POLB P06746 1/20 0.34
PTPN2 P17706 1/20 0.34
PTPN1 P18031 1/20 0.34
ALDH1A1 P00352 4/20 0.33
KDM4E B2RXH2 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
PTPN9 P43378 1/20 0.32
GAA P10253 2/20 0.31
JAK2 O60674 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6535134 0.79 TSHR (0.46) TSHRGABRA1GABRB2POLBPTPN2
SCHEMBL6534985 0.78 PTGS2 (0.47) TSHRALDH1A1KDM4EHPGD
SCHEMBL27980884 0.77 TSHR (0.49) TSHRGABRA1GABRB2POLBPTPN2
SCHEMBL6535409 0.77 ALDH1A1 (0.43) TSHRGABRA1GABRB2ALDH1A1LMNA
SCHEMBL6535437 0.75 TSHR (0.42) TSHRGABRA1GABRB2POLBALDH1A1
SCHEMBL27833260 0.73 TSHR (0.66) TSHRGABRA1GABRB2POLBPTPN2
SCHEMBL8002067 0.71 POLB (0.44) TSHRGABRA1GABRB2POLBKDM4E
Catechol SCHEMBL11651447 0.70 ALDH1A1 (0.48) TSHRPOLBALDH1A1KDM4ESMN1; SMN2
Catechol SCHEMBL11555211 0.70 ALDH1A1 (0.48) TSHRPOLBALDH1A1KDM4ESMN1; SMN2
SCHEMBL7998184 0.70 TSHR (0.39) TSHRGABRA1GABRB2POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958275-A4 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 UNIV VANDERBILT (US) 2004-12-01 EP disclosed
US-6284918-B1 ENZYME INHIBITORS VANDERBILT UNIVERSITY 2001-09-04 US disclosed
EP-0958275-A1 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 VANDERBILT UNIVERSITY (US) 1999-11-24 EP disclosed
US-5973191-A AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE VANDERBILT UNIVERSITY (US) 1999-10-26 US disclosed
WO-1998029382-A1 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 VANDERBILT UNIVERSITY (US) 1998-07-09 WO disclosed