SCHEMBL6535409

SCHEMBL6535409

Oc1ccccc1C(CCOc1ccccc1)SC(CCOc1ccccc1)c1ccccc1O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.43
RECQL P46063 1/20 0.43
KCNA3 P22001 1/20 0.42
TAAR1 Q96RJ0 1/20 0.39
PPARG P37231 1/20 0.38
PPARA Q07869 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CHRNB2 P17787 2/20 0.38
CHRNB4 P30926 2/20 0.38
CHRNA3 P32297 2/20 0.38
CHRNA7 P36544 2/20 0.38
CHRNA4 P43681 2/20 0.38
PKM P14618 1/20 0.38
DRD2 P14416 2/20 0.37
DRD4 P21917 2/20 0.37
DRD3 P35462 2/20 0.37
TSHR P16473 1/20 0.37
GABRA1 P14867 1/20 0.36
GABRB2 P47870 1/20 0.36
HDAC3 O15379 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6535415 0.79 ALDH1A1 (0.44) ALDH1A1RECQLKCNA3TAAR1PPARG
SCHEMBL6535128 0.77 TSHR (0.44) ALDH1A1TSHRGABRA1GABRB2LMNA
SCHEMBL7994698 0.77 PTGS2 (0.44) ALDH1A1PPARGPPARATDP1TSHR
SCHEMBL8002067 0.75 POLB (0.44) TDP1PKMTSHRGABRA1GABRB2
SCHEMBL7998184 0.70 TSHR (0.39) ALDH1A1RECQLTDP1TSHRGABRA1
SCHEMBL7996417 0.70 HDAC3 (0.41) ALDH1A1TSHRHDAC3HDAC4HDAC1
SCHEMBL2569851 0.69 KCNA3 (0.58) ALDH1A1RECQLKCNA3TAAR1PPARG
SCHEMBL8002056 0.69 TSHR (0.38) TSHRGABRA1GABRB2
SCHEMBL6535408 0.69 LMNA (0.44) ALDH1A1RECQLTSHRGABRA1GABRB2
SCHEMBL7984601 0.69 TSHR (0.38) TSHRGABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958275-A4 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 UNIV VANDERBILT (US) 2004-12-01 EP disclosed
US-6284918-B1 ENZYME INHIBITORS VANDERBILT UNIVERSITY 2001-09-04 US disclosed
EP-0958275-A1 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 VANDERBILT UNIVERSITY (US) 1999-11-24 EP disclosed
US-5973191-A AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE VANDERBILT UNIVERSITY (US) 1999-10-26 US disclosed
WO-1998029382-A1 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 VANDERBILT UNIVERSITY (US) 1998-07-09 WO disclosed