Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 19/20 | 0.64 |
| ▸ | CASP7 | P55210 | 11/20 | 0.59 |
| ▸ | CASP1 | P29466 | 7/20 | 0.59 |
| ▸ | CASP9 | P55211 | 4/20 | 0.59 |
| ▸ | CASP2 | P42575 | 3/20 | 0.59 |
| ▸ | CASP6 | P55212 | 3/20 | 0.59 |
| ▸ | CASP4 | P49662 | 2/20 | 0.59 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424164 | 0.95 | CASP3 (0.60) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535574 | 0.83 | CASP3 (0.76) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535570 | 0.83 | CASP3 (0.76) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535351 | 0.80 | CASP3 (0.68) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535352 | 0.80 | CASP3 (0.68) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL7484695 | 0.78 | CASP3 (0.71) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL1092160 | 0.77 | CASP3 (1.00) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535354 | 0.77 | CASP3 (1.00) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL1092156 | 0.77 | CASP3 (1.00) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL8263963 | 0.76 | CASP3 (0.65) | CASP3CASP7CASP1CASP9CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242081-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1242081-A1 | CASPASES AND APOPTOSIS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001022966-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-05 | — | — | WO | disclosed |