Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.67 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.64 |
| ▸ | MMP9 | P14780 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707107 | 0.91 | MAPK1 (0.77) | BRD4LMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL21378120 | 0.91 | BRD4 (0.68) | BRD4LMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL21378119 | 0.91 | BRD4 (0.68) | BRD4LMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL21378122 | 0.88 | MMP2 (0.69) | BRD4LMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL2707719 | 0.86 | HCRTR1 (0.80) | BRD4LMNAHCRTR1HCRTR2KMT2A | |
| SCHEMBL15682650 | 0.86 | BRD4 (0.62) | BRD4LMNAHCRTR1HCRTR2MMP2 | |
| SCHEMBL31609955 | 0.86 | HCRTR1 (0.61) | BRD4LMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL20156010 | 0.84 | MMP2 (0.66) | BRD4LMNAALDH1A1MMP2MMP9 | |
| SCHEMBL3699168 | 0.84 | HCRTR1 (0.78) | BRD4LMNAHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL21397757 | 0.84 | BRD4 (1.00) | BRD4LMNAHCRTR1HCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445870-B1 | 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | INST UNIV CIENCIA I TECNOLOGIA (ES) | 2018-10-31 | — | — | EP | disclosed |
| US-8455660-B2 | 1-(sulfonyl)-N-phenylpyrrolidine-2-carboxamides for the identification of biological and pharmacological activity | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S.A. (ES) | 2013-06-04 | — | — | US | disclosed |
| US-8455660-B2 | 1-(sulfonyl)-N-phenylpyrrolidine-2-carboxamides for the identification of biological and pharmacological activity | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S.A. (ES) | 2013-06-04 | — | — | US | disclosed |
| US-20120142936-A1 | 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | AMIRA THERAPEUTICS, S.L. (ES) | 2012-06-07 | — | — | US | disclosed |
| US-20120142936-A1 | 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | AMIRA THERAPEUTICS, S.L. (ES) | 2012-06-07 | — | — | US | disclosed |
| US-20120122950-A1 | LIBRARIES OF 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR DRUG DISCOVERY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| US-20120122950-A1 | LIBRARIES OF 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR DRUG DISCOVERY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| US-20120122709-A1 | LIBRARIES OF 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| US-20120122709-A1 | LIBRARIES OF 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) | 2012-05-17 | — | — | US | disclosed |
| EP-2452934-A1 | N-PHENYL-1-SULFONYL-2-PYRROLIDINE CARBOXAMIDES LIBRARIES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | Institut Univ. de Ciència i Tecnologia, S.A. (ES) | 2012-05-16 | — | — | EP | disclosed |
| EP-2447249-A1 | N-PHENYL-1-SULFONYL-2-PYRROLIDINE CARBOXAMIDE LIBRARIES FOR DRUG DISCOVERY | Institut Univ. de Ciència i Tecnologia, S.A. (ES) | 2012-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122709-A1 | LIBRARIES OF 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | AADAC, NCS1, CATSPER1 | BRD4 22/4885LMNA 3482/4885HCRTR1 1762/4885 |
| US-20120122950-A1 | LIBRARIES OF 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR DRUG DISCOVERY | NCS1, AADAC, CATSPER1 | BRD4 8/4885LMNA 3968/4885HCRTR1 2232/4885 |
| US-20120142936-A1 | 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY | NCS1, CATSPER1, AADAC | BRD4 12/4885LMNA 3071/4885HCRTR1 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.