SCHEMBL6535407

SCHEMBL6535407

O=C(OCc1ccccc1)OC(=O)C1CCNCC1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.47
ALDH1A1 P00352 3/20 0.47
GAA P10253 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
NMT1 P30419 1/20 0.45
HTR2C P28335 1/20 0.44
FABP7 O15540 1/20 0.43
FABP5 Q01469 1/20 0.43
CYP2C19 P33261 1/20 0.43
PLAT P00750 1/20 0.43
HTR1A P08908 1/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27724950 0.91 ALDH1A1 (0.54) TSHRALDH1A1GAASMN1; SMN2NPC1
SCHEMBL606466 0.88 TSHR (0.55) TSHRALDH1A1GAASMN1; SMN2NPC1
Hydrochloric Acid SCHEMBL3494457 0.87 TSHR (0.57) TSHRALDH1A1GAASMN1; SMN2NPC1
SCHEMBL27724941 0.87 ALDH1A1 (0.50) TSHRALDH1A1GAASMN1; SMN2NPC1
SCHEMBL434313 0.85 HTR2C (0.52) TSHRALDH1A1GAASMN1; SMN2NPC1
Alcohol SCHEMBL27541427 0.83 TSHR (0.53) TSHRALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL28687641 0.83 TSHR (0.53) TSHRALDH1A1GAASMN1; SMN2NPC1
SCHEMBL22338484 0.82 L3MBTL1 (0.47) TSHRALDH1A1GAASMN1; SMN2NPC1
SCHEMBL7412066 0.81 TSHR (0.48) TSHRALDH1A1GAASMN1; SMN2NPC1
SCHEMBL8692031 0.80 ALDH1A1 (0.53) TSHRALDH1A1GAASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113976072-B Preparation device and method of 4-formyl-N-CBZ piperidine 武汉青风凯默生物医药科技有限公司 2024-02-23 CN claimed
CN-118076599-A Dioxazines and their use in the treatment of GBA related diseases 泽拉丹麦有限公司 2024-05-24 CN disclosed
CN-113976072-B Preparation device and method of 4-formyl-N-CBZ piperidine 武汉青风凯默生物医药科技有限公司 2024-02-23 CN disclosed
EP-2956441-A1 MODULATORS OF VASOPRESSIN RECEPTORS WITH THERAPEUTIC POTENTIAL The Scripps Research Institute (US) 2015-12-23 EP disclosed
WO-2014127350-A1 MODULATORS OF VASOPRESSIN RECEPTORS WITH THERAPEUTIC POTENTIAL THE SCRIPPS RESEARCH INSTITUTE (US) 2014-08-21 WO disclosed
EP-1399160-A4 NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES MERCK & CO INC (US) 2004-08-25 EP disclosed
EP-1399160-A2 NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES Merck & Co., Inc. (US) 2004-03-24 EP disclosed
WO-2002100352-A2 NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES MERCK & CO., INC. (US) 2002-12-19 WO disclosed