Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4349161 | 0.86 | AR (0.64) | CYP19A1ALDH1A1L3MBTL1KMT2ACA2 | |
| SCHEMBL10837819 | 0.84 | KMT2A (0.64) | ALDH1A1NPC1RAB9AKMT2ACA2 | |
| SCHEMBL7946395 | 0.81 | KMT2A (0.61) | KMT2AGAAHTTMAPTMEN1 | |
| SCHEMBL24526461 | 0.80 | KMT2A (0.59) | L3MBTL1NPC1RAB9AKMT2ACA2 | |
| SCHEMBL11441022 | 0.80 | CYP1A2 (0.59) | CYP19A1ALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL18770196 | 0.80 | KMT2A (0.59) | ALDH1A1L3MBTL1NPC1RAB9AKMT2A | |
| SCHEMBL14686232 | 0.79 | CYP1A2 (0.67) | CYP19A1ALDH1A1KMT2AGAAMEN1 | |
| SCHEMBL27956824 | 0.78 | CA2 (0.59) | CYP19A1RAB9AKMT2ACA2CA12 | |
| SCHEMBL30586133 | 0.78 | AR (0.62) | CYP19A1ALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL4421032 | 0.78 | AR (0.62) | CYP19A1ALDH1A1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105283458-B | Preparation of tert-butyl 4- ((1R,2S,5R) -6- (benzyloxy) -7-oxo-1, 6-diazabicyclo [3.2.1] octane-2-carboxamido) piperidine-1-carboxylate | 默沙东公司 | 2018-05-22 | — | — | CN | claimed |
| EP-3008069-B1 | PREPARATION OF TERT-BUTYL 4-((1R,2S,5R)-6- (BENZYLOXY)-7-0X0-1,6-DIAZABICYCL0[3.2.I]OCTANE-2- CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE | MERCK SHARP & DOHME (US) | 2018-01-03 | — | — | EP | claimed |
| US-9604985-B2 | Process for the preparation of chiral tert-butyl 4-((1R,2S,5R)-6(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carb derivatives and (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide | MERCK SHARP & DOHME CORP. (US) | 2017-03-28 | — | — | US | claimed |
| US-20160122350-A1 | PROCESS FOR THE PREPARATION OF CHIRAL TERT-BUTYL 4-((1R,2S,5R)-6-(BENZYLOXY)-7-OXO-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE DERIVATIVES AND (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE | MERCK SHARP & DOHME CORP. (US) | 2016-05-05 | — | — | US | claimed |
| EP-3008069-A1 | PREPARATION OF TERT-BUTYL 4-((1R,2S,5R)-6- (BENZYLOXY)-7-0X0-1,6-DIAZABICYCL0[3.2.I]OCTANE-2- CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE | Merck Sharp & Dohme Corp. (US) | 2016-04-20 | — | — | EP | claimed |
| CN-105283458-A | Preparation of tert-butyl 4- ((1R,2S,5R) -6- (benzyloxy) -7-oxo-1, 6-diazabicyclo [3.2.1] octane-2-carboxamido) piperidine-1-carboxylate | MERCK SHARP & DOHME | 2016-01-27 | — | — | CN | claimed |
| WO-2014200786-A1 | PREPARATION OF TERT-BUTYL 4-((1R,2S,5R)-6- (BENZYLOXY)-7-0X0-1,6-DIAZABICYCL0[3.2.I]OCTANE-2- CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE | MERCK SHARP & DOHME CORP. (US) | 2014-12-18 | — | — | WO | claimed |
| CN-119707784-A | Process for preparing amino acid derivatives | 株式会社API | 2025-03-28 | — | — | CN | disclosed |
| WO-2025031214-A1 | UREA-CONTAINING TRICYCLIC β-LACTAMASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 成都四面体药物研究有限公司 | 2025-02-13 | — | — | WO | disclosed |
| CN-112930338-B | Process for preparing amino acid derivatives | 株式会社API | 2024-12-24 | — | — | CN | disclosed |
| CN-111943950-B | Preparation method of rilibatan | 山东安信制药有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-111072660-B | Simple preparation method of rilibatan | 新发药业有限公司 | 2021-05-18 | — | — | CN | disclosed |
| CN-111943950-A | Preparation method of rilibatan | 山东安信制药有限公司 | 2020-11-17 | — | — | CN | disclosed |
| US-20160122350-A1 | PROCESS FOR THE PREPARATION OF CHIRAL TERT-BUTYL 4-((1R,2S,5R)-6-(BENZYLOXY)-7-OXO-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE DERIVATIVES AND (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE | MERCK SHARP & DOHME CORP. (US) | 2016-05-05 | — | — | US | disclosed |
| EP-3008069-A1 | PREPARATION OF TERT-BUTYL 4-((1R,2S,5R)-6- (BENZYLOXY)-7-0X0-1,6-DIAZABICYCL0[3.2.I]OCTANE-2- CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE | Merck Sharp & Dohme Corp. (US) | 2016-04-20 | — | — | EP | disclosed |
| CN-105283458-A | Preparation of tert-butyl 4- ((1R,2S,5R) -6- (benzyloxy) -7-oxo-1, 6-diazabicyclo [3.2.1] octane-2-carboxamido) piperidine-1-carboxylate | MERCK SHARP & DOHME | 2016-01-27 | — | — | CN | disclosed |
| WO-2014200786-A1 | PREPARATION OF TERT-BUTYL 4-((1R,2S,5R)-6- (BENZYLOXY)-7-0X0-1,6-DIAZABICYCL0[3.2.I]OCTANE-2- CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE | MERCK SHARP & DOHME CORP. (US) | 2014-12-18 | — | — | WO | disclosed |
| EP-1098659-A4 | LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS | METAPHORE INC (US) | 2004-11-24 | — | — | EP | disclosed |
| EP-1098659-A2 | LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS | Metaphore, Inc. (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004868-A2 | LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS | METAPHORE, INC. (US) | 2000-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122350-A1 | PROCESS FOR THE PREPARATION OF CHIRAL TERT-BUTYL 4-((1R,2S,5R)-6-(BENZYLOXY)-7-OXO-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE DERIVATIVES AND (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE | CYP2W1, PGLS, GPKOW | CYP19A1 599/4885ALDH1A1 1298/4885L3MBTL1 3042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.