Flosequinan

Flosequinan

SCHEMBL6535622

Cn1cc([S+](C)[O-])c(=O)c2ccc(F)cc21.Cn1cc([S+](C)[O-])c(=O)c2ccc(F)cc21.S

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.46
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
IDO1 P14902 1/20 0.39
TDO2 P48775 1/20 0.39
DRD2 P14416 1/20 0.38
SLC6A4 P31645 1/20 0.38
CNR2 P34972 2/20 0.38
GSK3B P49841 4/20 0.37
PRKCA P17252 1/20 0.37
SCN9A Q15858 2/20 0.34
CDK2 P24941 2/20 0.33
CCNE2 O96020 1/20 0.33
CDK4 P11802 1/20 0.33
PRKACA P17612 1/20 0.33
PRKACG P22612 1/20 0.33
PRKACB P22694 1/20 0.33
CCND1 P24385 1/20 0.33
CCNE1 P24864 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flosequinan SCHEMBL122877 0.99 ATM (0.47) ATMKDM4EALDH1A1IDO1TDO2
Flosequinan SCHEMBL5441172 0.99 ATM (0.47) ATMKDM4EALDH1A1IDO1TDO2
Flosequinan SCHEMBL5442796 0.99 ATM (0.47) ATMKDM4EALDH1A1IDO1TDO2
SCHEMBL11390014 0.87 ALDH1A1 (0.50) ATMKDM4EALDH1A1DRD2SLC6A4
SCHEMBL5445367 0.83 ATM (0.43) ATMKDM4EALDH1A1IDO1TDO2
SCHEMBL5438058 0.83 ATM (0.43) ATMKDM4EALDH1A1IDO1TDO2
Flosequinan SCHEMBL7451233 0.83 ATM (0.40) ATMALDH1A1GSK3BPRKCASCN9A
SCHEMBL7317623 0.82 TP53 (0.38) KDM4EALDH1A1GSK3BPRKCACDK2
SCHEMBL5864364 0.82 ATM (0.43) ATMKDM4EALDH1A1IDO1TDO2
SCHEMBL5868247 0.82 ATM (0.43) ATMKDM4EALDH1A1IDO1TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313706-A4 METHOD FOR SYNTHESIZING FLOSEQUINAN FROM 4-FLUOROANTHRANILIC ACID R T ALAMO VENTURES I LLC (US) 2004-01-28 EP disclosed
EP-1313706-A1 METHOD FOR SYNTHESIZING FLOSEQUINAN FROM 4-FLUOROANTHRANILIC ACID R.T. Alamo Ventures I, LLC (US) 2003-05-28 EP disclosed
WO-2002018343-A1 METHOD FOR SYNTHESIZING FLOSEQUINAN FROM 4-FLUOROANTHRANILIC ACID R.T. ALAMO VENTURES I, LLC (US) 2002-03-07 WO disclosed
US-6307050-B1 CYCLIZATION WITH PHOSGENE; METHYLATION; REACTION WITH DIMSYLSODIUM; REACTION WITH TRIETHYL ORTHOFORMATE IN THE PRESENCE OF PIPERDINE AND ACETIC ACID R. T. ALAMO VENTURE I LLC 2001-10-23 US disclosed