Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 4/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10973832 | 0.85 | ALDH1A1 (0.45) | ALDH1A1LCKGLAMAPTTHRB | |
| SCHEMBL6536119 | 0.82 | ALDH1A1 (0.48) | ALDH1A1LCKGLAMAPTTHRB | |
| SCHEMBL6535986 | 0.80 | ALDH1A1 (0.46) | ALDH1A1LCKGLAMAPTTHRB | |
| SCHEMBL6536102 | 0.80 | ALDH1A1 (0.46) | ALDH1A1LCKGLAMAPTTHRB | |
| SCHEMBL4276345 | 0.79 | ALDH1A1 (0.42) | ALDH1A1LCKGLAMAPTTHRB | |
| SCHEMBL6535943 | 0.79 | ALDH1A1 (0.45) | ALDH1A1LCKGLAMAPTTHRB | |
| SCHEMBL27625888 | 0.73 | PDE4B (0.50) | ALDH1A1MAPTPDE4BPDE4APDE4C | |
| SCHEMBL29672073 | 0.73 | ERN1 (0.45) | ALDH1A1LCKGLAMAPTTHRB | |
| SCHEMBL6535962 | 0.73 | ALDH1A1 (0.40) | ALDH1A1LCKGLAMAPTTHRB | |
| SCHEMBL6535983 | 0.73 | ERN1 (0.45) | ALDH1A1LCKGLAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |