Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PTGIR | P43119 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8927890 | 0.83 | SMN1; SMN2 (0.65) | HRH3POLBKDM4EALDH1A1HPGD | |
| SCHEMBL5565916 | 0.82 | HRH3 (0.59) | LTA4HHRH3KDM4EALDH1A1KMT2A | |
| SCHEMBL15257179 | 0.79 | LTA4H (0.82) | LTA4HHRH3POLBKDM4EMAPT | |
| SCHEMBL14970684 | 0.79 | LTA4H (0.82) | LTA4HHRH3POLBKDM4EMAPT | |
| SCHEMBL23475000 | 0.79 | KDM4E (0.49) | LTA4HHRH3KDM4EKMT2AMEN1 | |
| SCHEMBL12486958 | 0.79 | LTA4H (0.58) | LTA4HHRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3163559 | 0.78 | HRH3 (0.63) | LTA4HHRH3ALDH1A1KMT2AHPGD | |
| SCHEMBL30272620 | 0.78 | HRH3 (0.63) | LTA4HHRH3POLBKDM4EMAPT | |
| SCHEMBL23474981 | 0.78 | ALDH1A1 (0.55) | LTA4HHRH3POLBKDM4EMAPT | |
| SCHEMBL23474980 | 0.78 | PSMB1 (0.50) | HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242081-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1001933-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1242081-A1 | CASPASES AND APOPTOSIS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001022966-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-05 | — | — | WO | disclosed |
| EP-1001933-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006367-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |