Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.63 |
| ▸ | PDE4A | P27815 | 5/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.63 |
| ▸ | MGAM | O43451 | 8/20 | 0.57 |
| ▸ | GAA | P10253 | 8/20 | 0.57 |
| ▸ | SI | P14410 | 8/20 | 0.57 |
| ▸ | MGAM2 | Q2M2H8 | 8/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HK2 | P52789 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL205626 | 0.83 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL29814561 | 0.80 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL29814564 | 0.80 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL13732796 | 0.79 | FYN (0.50) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL29034612 | 0.78 | MEN1 (0.53) | PDE4BPDE4APDE4CPDE4DHTT | |
| SCHEMBL3686460 | 0.77 | BACE1 (0.62) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL10601269 | 0.76 | SQOR (0.49) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL10536048 | 0.76 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL28243133 | 0.76 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DMGAM | |
| SCHEMBL24049723 | 0.76 | PGR (0.56) | PDE4BPDE4APDE4CPDE4DGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | claimed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | claimed |
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |