Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28132667 | 0.98 | LMNA (0.46) | LMNAAKR1C3CYP2C9CYP2C19KDM4E | |
| SCHEMBL18427387 | 0.82 | MTOR (0.36) | LMNACYP2C9CYP2C19KDM4EPIK3C3 | |
| Hydrochloric Acid SCHEMBL28134452 | 0.81 | MAPT (0.38) | LMNACYP2C9CYP2C19KDM4EPIK3C3 | |
| SCHEMBL10880845 | 0.78 | LMNA (0.47) | LMNAAKR1C3CYP2C9CYP2C19KDM4E | |
| SCHEMBL31051684 | 0.78 | LMNA (0.47) | LMNAAKR1C3CYP2C9CYP2C19KDM4E | |
| SCHEMBL27878581 | 0.78 | LMNA (0.47) | LMNAAKR1C3CYP2C9CYP2C19KDM4E | |
| SCHEMBL31051683 | 0.78 | LMNA (0.47) | LMNAAKR1C3CYP2C9CYP2C19KDM4E | |
| SCHEMBL137068 | 0.78 | LMNA (0.47) | LMNAAKR1C3CYP2C9CYP2C19KDM4E | |
| SCHEMBL27320448 | 0.78 | PIK3C3 (0.54) | LMNAPIK3C3 | |
| SCHEMBL27318560 | 0.78 | PIK3C3 (0.54) | LMNAPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012118562-A1 | COMPOSITIONS AND METHODS FOR TREATING DEPRESSION, ADHD AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS EMPLOYING NOVEL BUPROPION COMPOUNDS, AND METHODS FOR PRODUCTION AND USE OF NOVEL BUPROPION COMPOUNDS AND FORMULATIONS | RHINE PHARMACEUTICALS, LLC (US) | 2012-09-07 | — | — | WO | disclosed |
| EP-1434875-A4 | GENE POLYMORPHISMS AND RESPONSE TO TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2004-12-22 | — | — | EP | disclosed |
| EP-1434875-A1 | GENE POLYMORPHISMS AND RESPONSE TO TREATMENT | SmithKline Beecham Corporation (US) | 2004-07-07 | — | — | EP | disclosed |
| US-20030100479-A1 | Gene polymorphisms and response to treatment | DOW DAVID J (GB) | 2003-05-29 | — | — | US | disclosed |
| WO-2003018843-A1 | GENE POLYMORPHISMS AND RESPONSE TO TREATMENT | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100479-A1 | Gene polymorphisms and response to treatment | SLC6A2, SLC6A4, SLC6A3 | LMNA 3593/4885AKR1C3 555/4885CYP2C9 1326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.