Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14689569 | 0.87 | MAPT (0.60) | SMN1; SMN2MAPTTDP1 | |
| SCHEMBL28188901 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1GAARXFP1 | |
| SCHEMBL7591657 | 0.77 | SMN1; SMN2 (0.75) | SMN1; SMN2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL26768653 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL9419243 | 0.76 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EALDH1A1GAARXFP1 | |
| SCHEMBL989189 | 0.76 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EALDH1A1GAARXFP1 | |
| SCHEMBL9681370 | 0.76 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL6884345 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1GAARXFP1 | |
| SCHEMBL21708057 | 0.75 | CYP2C8 (0.50) | SMN1; SMN2MAPTTDP1CA1CA2 | |
| SCHEMBL12683255 | 0.74 | TDP1 (0.70) | MAPTTDP1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |