Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | GRM6 | O15303 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18803865 | 0.88 | ALDH1A1 (0.59) | ALDH1A1HPGDMAPTGAAKDM4E | |
| SCHEMBL27570075 | 0.87 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPTGAAKDM4E | |
| SCHEMBL31019062 | 0.86 | FGFR1 (0.57) | ALDH1A1HPGDMAPTGAAKDM4E | |
| SCHEMBL10455857 | 0.84 | CA12 (0.63) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL27636759 | 0.83 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTGAAKDM4E | |
| SCHEMBL4320540 | 0.82 | CA12 (0.72) | ALDH1A1HPGDMAPTGAAKDM4E | |
| SCHEMBL3869093 | 0.82 | TSHR (0.61) | ALDH1A1HPGDMAPTGAAKDM4E | |
| SCHEMBL4002652 | 0.81 | CA12 (0.69) | ALDH1A1HPGDMAPTGAAKDM4E | |
| SCHEMBL30536599 | 0.81 | CA12 (0.69) | ALDH1A1HPGDMAPTGAAKDM4E | |
| SCHEMBL9683905 | 0.81 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |