SCHEMBL6537500

SCHEMBL6537500

Cc1ccc(N)c2nccc(Cl)c12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.41
CYP3A4 P08684 3/20 0.39
LMNA P02545 1/20 0.38
MMP14 P50281 1/20 0.37
CCR1 P32246 1/20 0.36
CCR5 P51681 1/20 0.36
CCR8 P51685 1/20 0.36
NOS3 P29474 5/20 0.35
NOS2 P35228 5/20 0.35
ALDH1A1 P00352 3/20 0.33
TDP1 Q9NUW8 2/20 0.33
CASP1 P29466 1/20 0.33
TSHR P16473 1/20 0.33
CD44 P16070 1/20 0.33
CCNT1 O60563 1/20 0.33
CCNA2 P20248 1/20 0.33
CDK2 P24941 1/20 0.33
CDK9 P50750 1/20 0.33
CCNA1 P78396 1/20 0.33
CDK5 Q00535 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6537373 0.84 NR4A2 (0.46) NR4A2CYP3A4LMNAMMP14ALDH1A1
SCHEMBL31565251 0.84 NR4A2 (0.46) NR4A2CYP3A4LMNAMMP14ALDH1A1
SCHEMBL6537560 0.79 CD44 (0.39) NR4A2CYP3A4LMNAMMP14CCR1
SCHEMBL15146338 0.79 CCR1 (0.45) NR4A2CYP3A4LMNAMMP14CCR1
SCHEMBL6537949 0.77 G6PD (0.44) NR4A2CYP3A4MMP14ALDH1A1TDP1
SCHEMBL9032891 0.76 CCR1 (0.46) NR4A2CYP3A4LMNAMMP14CCR1
SCHEMBL6538359 0.74 CYP3A4 (0.39) CYP3A4LMNACCR1CCR5CCR8
SCHEMBL7696376 0.73 NR4A2 (0.40) NR4A2CYP3A4LMNAALDH1A1TDP1
SCHEMBL6538129 0.73 AXL (0.35) NR4A2CYP3A4CCR1CCR5CCR8
SCHEMBL6537530 0.71 MEN1 (0.55) CYP3A4LMNAALDH1A1TDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876345-B1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO (JP) 2004-08-18 EP disclosed
US-6008230-A TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0876345-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-11 EP disclosed
WO-1997014681-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-04-24 WO disclosed