Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD44 | P16070 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 3/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537500 | 0.79 | NR4A2 (0.41) | CD44NR4A2MMP14CYP3A4NOS3 | |
| SCHEMBL31565251 | 0.74 | NR4A2 (0.46) | NR4A2MMP14CYP3A4TSHRMAPK1 | |
| SCHEMBL6537373 | 0.74 | NR4A2 (0.46) | NR4A2MMP14CYP3A4TSHRMAPK1 | |
| SCHEMBL6538008 | 0.73 | MEN1 (0.49) | CYP3A4TSHRMAPK1MEN1KMT2A | |
| SCHEMBL6537871 | 0.70 | NR4A2 (0.43) | NR4A2MMP14CYP3A4NOS3NOS2 | |
| SCHEMBL6971396 | 0.69 | NOS2 (0.45) | CYP3A4NOS3NOS2TSHRMAPK1 | |
| SCHEMBL5447339 | 0.68 | HSP90AA1 (0.59) | MMP14NOS3NOS2G6PDCCR1 | |
| SCHEMBL6537949 | 0.68 | G6PD (0.44) | NR4A2MMP14CYP3A4G6PDTSHR | |
| SCHEMBL8112332 | 0.67 | MEN1 (0.49) | CYP3A4TSHRMAPK1MEN1KMT2A | |
| SCHEMBL14389206 | 0.67 | NSD2 (0.47) | CYP3A4NOS3NOS2G6PDCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |