Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Procaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 5/20 | 0.62 |
| ▸ | SCN2A known ✓ | Q99250 | 5/20 | 0.62 |
| ▸ | SCN3A known ✓ | Q9NY46 | 5/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.89 |
| ▸ | MAOA | P21397 | 4/20 | 0.89 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.89 |
| ▸ | TSHR | P16473 | 4/20 | 0.89 |
| ▸ | HTR3A | P46098 | 2/20 | 0.89 |
| ▸ | BLM | P54132 | 1/20 | 0.86 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.86 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Procaine SCHEMBL3524 | 0.94 | CYP2D6 (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL6901191 | 0.93 | BLM (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL3422994 | 0.93 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL5311049 | 0.93 | BLM (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL3731588 | 0.93 | BLM (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL6061234 | 0.93 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL27720 | 0.93 | BLM (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL9050778 | 0.93 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL11047275 | 0.93 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL28977033 | 0.93 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478913-A | CHO cell culture medium and application thereof | 苏州依科赛生物科技股份有限公司 | 2023-07-25 | — | — | CN | claimed |
| CN-116867483-A | Kit and method for inducing cardioversion in a subject suffering from atrial arrhythmia | 英凯达治疗公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-116478913-B | CHO cell culture medium and application thereof | 苏州依科赛生物科技股份有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-116478913-A | CHO cell culture medium and application thereof | 苏州依科赛生物科技股份有限公司 | 2023-07-25 | — | — | CN | disclosed |
| US-20040072769-A1 | Methods for design and selection of short double-stranded oligonucleotides, and compounds of gene drugs | YIN JAMES QINWEI (US) | 2004-04-15 | — | — | US | disclosed |