SCHEMBL6537945

SCHEMBL6537945

COCc1cnc2c([N+](=O)[O-])cc(C)cc2c1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.40
NPC1 O15118 2/20 0.37
GPR35 Q9HC97 1/20 0.36
S1PR4 O95977 1/20 0.36
ALDH1A1 P00352 7/20 0.35
LMNA P02545 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
CYP2D6 P10635 1/20 0.35
MAPT P10636 3/20 0.33
CYP3A4 P08684 2/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
PIM3 Q86V86 1/20 0.33
KMT2A Q03164 2/20 0.33
RAB9A P51151 1/20 0.33
POLB P06746 1/20 0.33
VCAM1 P19320 1/20 0.33
TDP1 Q9NUW8 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6537614 0.81 KMT2A (0.51) SMN1; SMN2NPC1ALDH1A1LMNACYP1A2
SCHEMBL6536893 0.79 LMNA (0.42) ALDH1A1LMNAKDM4E
SCHEMBL6538000 0.74 KMT2A (0.38) SMN1; SMN2NPC1ALDH1A1LMNAMAPT
SCHEMBL6537736 0.70 MEN1 (0.61) SMN1; SMN2GPR35S1PR4ALDH1A1LMNA
SCHEMBL18579528 0.68 TSHR (0.56) SMN1; SMN2NPC1GPR35S1PR4ALDH1A1
SCHEMBL1627980 0.68 VCAM1 (0.43) ALDH1A1LMNACYP1A2CYP2C9CYP2C19
SCHEMBL6538075 0.68 KMT2A (0.49) SMN1; SMN2NPC1ALDH1A1LMNACYP1A2
SCHEMBL6537779 0.68 KMT2A (0.48) SMN1; SMN2NPC1ALDH1A1LMNACYP1A2
SCHEMBL11561732 0.67 TSHR (0.42) GPR35ALDH1A1LMNACYP3A4TSHR
SCHEMBL24716158 0.67 MEN1 (0.40) SMN1; SMN2S1PR4ALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876345-B1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO (JP) 2004-08-18 EP disclosed
US-6008230-A TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0876345-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-11 EP disclosed
WO-1997014681-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-04-24 WO disclosed