⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Squamolone SCHEMBL1051735 | 0.85 | — | — | |
| Squamolone SCHEMBL28367081 | 0.83 | LMNA (0.57) | — | |
| SCHEMBL4702017 | 0.83 | LMNA (0.52) | — | |
| SCHEMBL1424272 | 0.81 | LMNA (0.50) | — | |
| SCHEMBL15233814 | 0.78 | LMNA (0.44) | — | |
| SCHEMBL17224707 | 0.77 | — | — | |
| SCHEMBL2225143 | 0.76 | — | — | |
| SCHEMBL14140164 | 0.74 | — | — | |
| SCHEMBL4728242 | 0.74 | — | — | |
| SCHEMBL12104208 | 0.73 | LMNA (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170218353-A1 | Ligand-Directed Covalent Modification of Protein | CELGENE CAR LLC (BM) | 2017-08-03 | — | — | US | disclosed |
| US-20170218353-A1 | Ligand-Directed Covalent Modification of Protein | CELGENE CAR LLC (BM) | 2017-08-03 | — | — | US | disclosed |
| US-20110269244-A1 | LIGAND-DIRECTED COVALENT MODIFICATION OF PROTEIN | CELGENE CAR LLC (BM) | 2011-11-03 | — | — | US | disclosed |
| US-20110269244-A1 | LIGAND-DIRECTED COVALENT MODIFICATION OF PROTEIN | CELGENE CAR LLC (BM) | 2011-11-03 | — | — | US | disclosed |
| EP-0595557-B1 | New substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO INC (US) | 2004-06-30 | — | — | EP | disclosed |
| EP-0755262-A4 | COMPOSITION FOR THE TREATMENT OF LUNG DISEASE | MERCK & CO INC (US) | 1997-05-07 | — | — | EP | disclosed |
| EP-0755262-A1 | COMPOSITION FOR THE TREATMENT OF LUNG DISEASE | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| CN-1068815-A | Be used as the new substituted azetidinone of anti-inflammatory and antidegenerative agent | MERCK & CO INC (US) | 1993-02-10 | — | — | CN | disclosed |