Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424272 | 0.98 | LMNA (0.50) | LMNATSHRMITFSMN1; SMN2KMT2A | |
| Squamolone SCHEMBL1051735 | 0.93 | — | — | |
| Squamolone SCHEMBL28367081 | 0.91 | LMNA (0.57) | LMNATSHRMITFSMN1; SMN2KMT2A | |
| SCHEMBL6538147 | 0.83 | — | — | |
| SCHEMBL7687599 | 0.81 | LMNA (0.56) | LMNATSHRMITFSMN1; SMN2KMT2A | |
| SCHEMBL131845 | 0.79 | LMNA (0.54) | LMNATSHRMITFSMN1; SMN2KMT2A | |
| SCHEMBL1238335 | 0.79 | LMNA (0.54) | LMNATSHRMITFSMN1; SMN2KMT2A | |
| SCHEMBL5181091 | 0.79 | LMNA (0.54) | LMNATSHRMITFSMN1; SMN2KMT2A | |
| SCHEMBL8379227 | 0.79 | LMNA (0.54) | LMNATSHRMITFSMN1; SMN2KMT2A | |
| SCHEMBL4059818 | 0.77 | LMNA (0.52) | LMNATSHRMITFSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101312724-A | Tetrahydro-indazolyl cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-26 | — | — | CN | claimed |
| EP-1931336-A1 | TETRAHYDRO-INDAZOLYL CANNABINOID MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-06-18 | — | — | EP | claimed |
| US-20070117857-A1 | Substituted 3-amido-tetrahydro-indazolyl cannabinoid modulators | JANSSEN PHARMACEUTICA, N.V. | 2007-05-24 | — | — | US | claimed |
| WO-2007038045-A1 | TETRAHYDRO-INDAZOLYL CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-05 | — | — | WO | claimed |
| EP-3917513-A1 | SREBP INHIBITORS COMPRISING A THIOPHENE CENTRAL RING | Capulus Therapeutics, LLC (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020159889-A1 | SREBP INHIBITORS COMPRISING A THIOPHENE CENTRAL RING | CAPULUS THERAPEUTICS, LLC (US) | 2020-08-06 | — | — | WO | disclosed |
| CN-101312724-A | Tetrahydro-indazolyl cannabinoid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-26 | — | — | CN | disclosed |
| EP-1966194-A2 | SUBSTITUTED 5-HETEROARYL-1-PHENYL-PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-10 | — | — | EP | disclosed |
| EP-1931336-A1 | TETRAHYDRO-INDAZOLYL CANNABINOID MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007061948-A2 | SUBSTITUTED 5-HETEROARYL-1-PHENYL-PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-05-31 | — | — | WO | disclosed |
| US-20070117857-A1 | Substituted 3-amido-tetrahydro-indazolyl cannabinoid modulators | JANSSEN PHARMACEUTICA, N.V. | 2007-05-24 | — | — | US | disclosed |
| US-20070117858-A1 | SUBSTITUTED 5-HETEROARYL-1-PHENYL-PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-05-24 | — | — | US | disclosed |
| WO-2007038045-A1 | TETRAHYDRO-INDAZOLYL CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117857-A1 | Substituted 3-amido-tetrahydro-indazolyl cannabinoid modulators | CNR2, CNR1, GPR18 | LMNA 3709/4885TSHR 1203/4885MITF 4133/4885 |
| US-20070117858-A1 | SUBSTITUTED 5-HETEROARYL-1-PHENYL-PYRAZOLE CANNABINOID MODULATORS | CNR1, CNR2, GPR18 | LMNA 4037/4885TSHR 1638/4885MITF 3505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.