Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5546396 | 0.85 | AR (0.44) | TDP1CYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL3322133 | 0.81 | TP53 (0.41) | TDP1CYP1A2CYP2D6NR2F2ALDH1A1 | |
| SCHEMBL5546274 | 0.78 | CA2 (0.36) | ALDH1A1KMT2ALMNAUBE2NTP53 | |
| SCHEMBL14774993 | 0.78 | KMT2A (0.36) | TDP1MEN1KMT2ACTSKGAA | |
| SCHEMBL2953965 | 0.76 | RAB9A (0.42) | TDP1CYP1A2CYP2D6ALDH1A1HPGD | |
| SCHEMBL6212441 | 0.73 | PDE7A (0.54) | ALDH1A1HPGDMEN1KMT2APOLB | |
| SCHEMBL1436075 | 0.72 | CYP2D6 (0.50) | TDP1CYP1A2CYP2D6NR2F2ALDH1A1 | |
| SCHEMBL6542305 | 0.72 | TDP1 (0.57) | TDP1CYP1A2NR2F2ALDH1A1HPGD | |
| SCHEMBL4273513 | 0.72 | TDP1 (0.57) | TDP1CYP1A2NR2F2ALDH1A1HPGD | |
| SCHEMBL2320892 | 0.71 | MAOA (0.43) | CYP1A2CYP2D6ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0382411-B1 | Delivery of cytotoxic agents | LILLY CO ELI (US) | 1994-12-07 | — | — | EP | claimed |
| WO-1994001137-A1 | METHOD FOR DELIVERY OF CYTOTOXIC AGENTS AND COMPONENTS THEREOF | HYBRITECH INCORPORATED (US) | 1994-01-20 | — | — | WO | claimed |
| EP-0382411-A2 | Delivery of cytotoxic agents | ELI LILLY AND COMPANY (US) | 1990-08-16 | — | — | EP | claimed |
| EP-1294730-A4 | NOVEL CEPHALOSPORIN COMPOUNDS AND PROCESS FOR PREPARING THE SAME | LG CHEM INVESTMENT LTD (KR) | 2004-01-14 | — | — | EP | disclosed |
| EP-1294730-A2 | NOVEL CEPHALOSPORIN COMPOUNDS AND PROCESS FOR PREPARING THE SAME | LG Chem Investment, Ltd. (KR) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002000616-A2 | NOVEL CEPHALOSPORIN COMPOUNDS AND PROCESS FOR PREPARING THE SAME | LG LIFE SCIENCES LTD (KR) | 2002-01-03 | — | — | WO | disclosed |
| EP-0382411-B1 | Delivery of cytotoxic agents | LILLY CO ELI (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994001137-A1 | METHOD FOR DELIVERY OF CYTOTOXIC AGENTS AND COMPONENTS THEREOF | HYBRITECH INCORPORATED (US) | 1994-01-20 | — | — | WO | disclosed |
| US-5011938-A | Antimicrobials | ELI LILLY AND COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0382411-A2 | Delivery of cytotoxic agents | ELI LILLY AND COMPANY (US) | 1990-08-16 | — | — | EP | disclosed |
| US-4940718-A | BACTERICIDES | ELI LILLY AND COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0202046-A1 | 7-Substituted bicyclic pyrazolidinones | ELI LILLY AND COMPANY (US) | 1986-11-20 | — | — | EP | disclosed |
| US-4604386-A | CONTROL OF GRAMPOSITIVE BACTERIA | ELI LILLY AND COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0168222-A2 | 3-(Alkynylalkyloxy) Cephalosporins | ELI LILLY AND COMPANY (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4145538-A | 3-Carbamyloxymethyl-cephalosporins | ELI LILLY AND COMPANY (US) | 1979-03-20 | — | — | US | disclosed |
| US-4012380-A | 7-Acylamino-3-acyl-2(or 3)cephems | ELI LILLY AND COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
| US-4001226-A | 3-(SUBSTITUTED)CARBONYLAMINO CEPHEM DERIVATIVES | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3953436-A | 3,4-Dicarboxycephalosporins and derivatives | ELI LILLY AND COMPANY (US) | 1976-04-27 | — | — | US | disclosed |