Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6541858 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL11760691 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL28054874 | 0.70 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL19124537 | 0.69 | LMNA (0.46) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL6120105 | 0.69 | LMNA (0.42) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL8329339 | 0.68 | LMNA (0.47) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL3134099 | 0.68 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL3243742 | 0.68 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL28403527 | 0.68 | LMNA (0.47) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL28293342 | 0.68 | LMNA (0.47) | SMN1; SMN2MEN1GAAKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408980-A4 | NOVEL QUINAZOLINES AND USES THEREOF | ARIAD PHARMA INC (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1408980-A2 | NOVEL QUINAZOLINES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003000188-A2 | NOVEL QUINAZOLINES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |