Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134099 | 0.87 | SMN1; SMN2 (0.48) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL10651815 | 0.86 | LMNA (0.46) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL25512278 | 0.84 | LMNA (0.44) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL28403527 | 0.84 | LMNA (0.47) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL1171499 | 0.83 | POLB (0.47) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL8329336 | 0.81 | LMNA (0.44) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL15631966 | 0.81 | LMNA (0.44) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL28049800 | 0.80 | POLB (0.45) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL18404733 | 0.80 | POLB (0.45) | LMNASMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL8327638 | 0.80 | PIN1 (0.41) | LMNASMN1; SMN2GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |