Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | TGM1 | P22735 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 2/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652015 | 0.86 | CHRNB2 (0.48) | GPR119NR1H2USP30CHRNB2CHRNB4 | |
| SCHEMBL652300 | 0.86 | CHRNB2 (0.48) | GPR119NR1H2USP30CHRNB2CHRNB4 | |
| SCHEMBL3576741 | 0.83 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL653364 | 0.81 | CHRNB2 (0.51) | GPR119CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL649591 | 0.81 | CHRNB2 (0.51) | GPR119NR1H2USP30CHRNB2CHRNB4 | |
| SCHEMBL651995 | 0.81 | CHRNB2 (0.51) | GPR119CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL651511 | 0.81 | CHRNB2 (0.38) | GPR119NR1H2USP30F13A1TGM2 | |
| SCHEMBL652092 | 0.78 | GPR119 (0.37) | GPR119NR1H2USP30CHRNB2CHRNB4 | |
| SCHEMBL653201 | 0.78 | GPR119 (0.37) | GPR119NR1H2USP30CHRNB2CHRNB4 | |
| SCHEMBL4113401 | 0.77 | GPR119 (0.47) | GPR119USP30CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |