Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6541894 | 0.85 | ELANE (0.38) | ELANEHSD11B1LMNAMAPTCA12 | |
| SCHEMBL6542043 | 0.84 | HSD11B1 (0.36) | ELANEHSD11B1LMNAMAPTTP53 | |
| SCHEMBL6542189 | 0.81 | HSD11B1 (0.42) | ELANEHSD11B1LMNAMAPTCA12 | |
| SCHEMBL6542021 | 0.78 | MAPT (0.40) | MAPTCA12CA9KDM4ECYP1A2 | |
| SCHEMBL6542499 | 0.77 | HSD11B1 (0.47) | ELANEHSD11B1LMNAKDM4EUSP2 | |
| SCHEMBL6541959 | 0.74 | EDNRA (0.40) | HSD11B1LMNAUSP2HPGD | |
| SCHEMBL6542556 | 0.74 | EDNRA (0.37) | HSD11B1LMNASMN1; SMN2KDM4EHPGD | |
| SCHEMBL6542004 | 0.74 | HSD11B1 (0.45) | ELANEHSD11B1LMNAMAPTTP53 | |
| SCHEMBL6542551 | 0.72 | LMNA (0.65) | ELANELMNASMN1; SMN2CA12CA2 | |
| SCHEMBL6542020 | 0.71 | EDNRA (0.49) | LMNAMAPTSMN1; SMN2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009743-B1 | CERTAIN BENZOTHIAZINE DIOXIDE ENDOTHELIN ANTAGONISTS AND PROCESSES FOR THEIR PREPARATION | WARNER LAMBERT CO (US) | 2004-06-30 | — | — | EP | claimed |