Sugi Predict

Sugi Predict / Compounds / SCHEMBL654302

SCHEMBL654302

SCHEMBL654302

COc1ccc(N)cc1-c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGDR2 Q9Y5Y4 1/20 0.57
▸ MAOA P21397 1/20 0.49
▸ MAOB P27338 1/20 0.49
▸ KDM4C Q9H3R0 1/20 0.47
▸ NTRK1 P04629 1/20 0.46
▸ KDM4E B2RXH2 3/20 0.46
▸ ALDH1A1 P00352 3/20 0.46
▸ USP2 O75604 1/20 0.46
▸ MAPT P10636 3/20 0.44
▸ GAA P10253 2/20 0.44
▸ NCOA1 Q15788 1/20 0.44
▸ NCOA3 Q9Y6Q9 1/20 0.44
▸ LMNA P02545 1/20 0.44
▸ TSHR P16473 1/20 0.44
▸ MAPK1 P28482 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ PGR P06401 1/20 0.44
▸ BRD4 O60885 1/20 0.44
▸ NR4A1 P22736 1/20 0.43
▸ ADORA1 P30542 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL654301 0.98 PTGDR2 (0.55) PTGDR2MAOAMAOBKDM4CNTRK1
SCHEMBL3784958 0.88 NTRK1 (0.49) PTGDR2KDM4CNTRK1KDM4EALDH1A1
SCHEMBL3789262 0.87 FYN (0.51) PTGDR2MAOANTRK1KDM4EALDH1A1
SCHEMBL29788128 0.85 CYP1A1 (0.50) PTGDR2KDM4EALDH1A1MAPTGAA
SCHEMBL2617558 0.85 CYP1A1 (0.50) PTGDR2KDM4EALDH1A1MAPTGAA
SCHEMBL4324881 0.84 PTGDR2 (0.60) PTGDR2MAOAMAOBALDH1A1NCOA1
SCHEMBL27185972 0.83 ALDH1A1 (0.55) KDM4CKDM4EALDH1A1USP2MAPT
Hydrochloric Acid SCHEMBL2097510 0.83 CYP1A1 (0.49) PTGDR2KDM4EALDH1A1MAPTGAA
SCHEMBL5841896 0.83 TDP1 (0.54) NTRK1KDM4EALDH1A1USP2MAPT
SCHEMBL6259929 0.82 CYP3A4 (0.56) MAOBKDM4EALDH1A1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1066257-A2 HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE Sugen, Inc. (US) 2001-01-10 — — EP claimed
WO-1999048868-A9 HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE SUGEN INC (US) 2000-04-20 — — WO claimed
WO-1999048868-A2 HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE SUGEN, INC. (US) 1999-09-30 — — WO claimed
WO-2025100475-A1 COMPOSITION FOR IMAGE RECORDING AND METHOD FOR PRODUCING SAME キヤノン株式会社 2025-05-15 — — WO disclosed
US-20240158355-A1 BET SUBFAMILY INHIBITORS AND METHODS USING SAME BAYLOR COLLEGE MEDICINE (US) 2024-05-16 — — US disclosed
WO-2022159454-A1 BET SUBFAMILY INHIBITORS AND METHODS USING SAME BAYLOR COLLEGE OF MEDICINE (US) 2022-07-28 — — WO disclosed
US-11091488-B2 1-cyano-pyrrolidine derivatives as inhibitors of USP30 MISSION THERAPEUTICS LIMITED (GB) 2021-08-17 — — US disclosed
US-11091488-B2 1-cyano-pyrrolidine derivatives as inhibitors of USP30 MISSION THERAPEUTICS LIMITED (GB) 2021-08-17 — — US disclosed
CN-108290861-B 1-cyano-pyrrolidine derivatives as USP30 inhibitors 特殊治疗有限公司 2021-05-25 — — CN disclosed
US-11007193-B2 2,4-pyrimidinediamine compounds and their uses RIGEL PHARMACEUTICALS, INC. (US) 2021-05-18 — — US disclosed
US-10828301-B2 2,4-pyrimidinediamine compounds and their uses Rigel Pharmceuticals, Inc. (US) 2020-11-10 — — US disclosed
WO-2002046129-A2 INHIBITORS OF HISTONE DEACETYLASE ABBOTT LABORATORIES (US) 2002-06-13 — — WO disclosed
EP-1066257-A2 HETEROCYLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE Sugen, Inc. (US) 2001-01-10 — — EP disclosed
WO-1999048868-A9 HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE SUGEN INC (US) 2000-04-20 — — WO disclosed
WO-1999048868-A2 HETEROCYCLIC CLASSES OF COMPOUNDS FOR THE MODULATING TYROSINE PROTEIN KINASE SUGEN, INC. (US) 1999-09-30 — — WO disclosed
EP-0153954-A1 INSECTICIDAL SUBSTITUTED BIPHENYL BENZOYLUREAS FMC Corporation (US) 1985-09-11 — — EP disclosed
WO-1985001047-A1 INSECTICIDAL SUBSTITUTED BIPHENYL BENZOYLUREAS FMC CORPORATION (US) 1985-03-14 — — WO disclosed
EP-0006218-B1 SUBSTITUTED AMINO ACIDS, THEIR USE AND PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1982-05-26 — — EP disclosed
US-4243678-A GASTROINTESTINAL DISORDERS, LIVER DISORDERS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1981-01-06 — — US disclosed
EP-0006218-A1 Substituted amino acids, their use and preparation and pharmaceutical compositions containing them Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1980-01-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11091488-B2 1-cyano-pyrrolidine derivatives as inhibitors of USP30 USP30, USP1, USP20 PTGDR2 4642/4885MAOA 3357/4885MAOB 3233/4885
US-20240158355-A1 BET SUBFAMILY INHIBITORS AND METHODS USING SAME BRDT, BRD3, BRD2 PTGDR2 1341/4885MAOA 3837/4885MAOB 3381/4885
US-11007193-B2 2,4-pyrimidinediamine compounds and their uses FCER2, FCGR1A, FCGR2A PTGDR2 157/4885MAOA 784/4885MAOB 756/4885
US-10828301-B2 2,4-pyrimidinediamine compounds and their uses FCER2, FCGR1A, FCGR2A PTGDR2 157/4885MAOA 784/4885MAOB 756/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.