Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78618 | 0.89 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL65338 | 0.79 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL79378 | 0.79 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL65337 | 0.79 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL79894 | 0.78 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL65406 | 0.76 | REN (0.49) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL66535 | 0.75 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL5072329 | 0.73 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL5072308 | 0.71 | SLC6A4 (0.76) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8171105 | 0.70 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |