Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.44 |
| ▸ | HTR7 | P34969 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64882 | 0.79 | CA1 (0.42) | CA12CA1CA2CA4CA7 | |
| SCHEMBL1526352 | 0.77 | CA1 (0.41) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4586248 | 0.77 | TAAR1 (0.41) | HTR2AHTR2CHTR2BCA12CA1 | |
| SCHEMBL28069112 | 0.77 | CA1 (0.41) | CA12CA1CA2CA4CA7 | |
| SCHEMBL6203845 | 0.77 | CA1 (0.41) | CA12CA1CA2CA4CA7 | |
| SCHEMBL7838938 | 0.76 | CA1 (0.39) | HTR1ACA12CA1CA2CA4 | |
| SCHEMBL5178854 | 0.75 | TSHR (0.37) | SLC6A4SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL18706055 | 0.74 | HTR7 (0.42) | SLC6A4SLC6A2SLC6A3HTR7HTR2A | |
| SCHEMBL8480841 | 0.74 | ENPP2 (0.38) | CA12CA1CA2CA4CA7 | |
| SCHEMBL12816605 | 0.74 | CA1 (0.38) | CA12CA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190071416-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-03-07 | — | — | US | claimed |
| EP-3371151-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | Agency For Science, Technology And Research (SG) | 2018-09-12 | — | — | EP | claimed |
| WO-2017061957-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-04-13 | — | — | WO | claimed |
| WO-2003078380-A2 | PROCESS FOR PREPARING TRAMADOL HYDROCHLORIDE AND/OR TRAMADOL MOMOHYDRATE | JUBILANT ORGANOSYS LTD (GB) | 2003-09-25 | — | — | WO | claimed |
| US-20230157991-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ACUTE AND CHRONIC PAIN, CONTAINING POLMACOXIB AND TRAMADOL | CRYSTALGENOMICS INC (KR) | 2023-05-25 | — | — | US | disclosed |
| US-20200276152-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ACUTE AND CHRONIC PAIN, CONTAINING POLMACOXIB AND TRAMADOL | CRYSTALGENOMICS, INC. (KR) | 2020-09-03 | — | — | US | disclosed |
| EP-3682876-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ACUTE AND CHRONIC PAIN, CONTAINING POLMACOXIB AND TRAMADOL | Crystalgenomics, Inc. (KR) | 2020-07-22 | — | — | EP | disclosed |
| US-20190071416-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-03-07 | — | — | US | disclosed |
| EP-3371151-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | Agency For Science, Technology And Research (SG) | 2018-09-12 | — | — | EP | disclosed |
| CN-107648228-A | Compound that a kind of Parecoxib Sodium forms with tramadol hydrochloride and application thereof | 珠海赛隆药业股份有限公司 | 2018-02-02 | — | — | CN | disclosed |
| WO-2017061957-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-04-13 | — | — | WO | disclosed |
| CN-106214671-A | A kind of preparation containing tramadol hydrochloride and acetaminophen and preparation method thereof | 山西好医生药业有限公司 | 2016-12-14 | — | — | CN | disclosed |
| EP-1077923-B1 | AN IMPROVED SYNTHESIS AND PURIFICATION OF (R*,R*)-2- (DIMETHYLAMINO) METHYL]-1-( 3-METHOXYPHENYL) CYCLOHEXANOL HYDROCHLORIDE | MALLINCKRODT INC (US) | 2004-01-02 | — | — | EP | disclosed |
| EP-1077923-A1 | AN IMPROVED SYNTHESIS AND PURIFICATION OF (R*,R*)-2- (DIMETHYLAMINO) METHYL]-1-( 3-METHOXYPHENYL) CYCLOHEXANOL HYDROCHLORIDE | Mallinckrodt Inc. (US) | 2001-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071416-A1 | COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS | SMYD3, SMYD2, EHMT1 | SLC6A4 1244/4885SLC6A2 1484/4885SLC6A3 415/4885 |
| US-20230157991-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ACUTE AND CHRONIC PAIN, CONTAINING POLMACOXIB AND TRAMADOL | PTGES3, PTGER3, PTGER1 | SLC6A4 1368/4885SLC6A2 1690/4885SLC6A3 1650/4885 |
| US-20200276152-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ACUTE AND CHRONIC PAIN, CONTAINING POLMACOXIB AND TRAMADOL | PTGES3, PTGER3, PTGER1 | SLC6A4 1486/4885SLC6A2 1711/4885SLC6A3 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.