Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 3/20 | 0.33 |
| ▸ | PCNA | P12004 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | THRA | P10827 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6543660 | 0.85 | ESRRA (0.37) | ESRRAPCNATHRBABL1THRA | |
| SCHEMBL6543097 | 0.84 | PGR (0.33) | ABL1 | |
| SCHEMBL6544202 | 0.84 | ABL1 (0.32) | ABL1 | |
| SCHEMBL6543795 | 0.84 | AR (0.36) | THRBTHRA | |
| SCHEMBL6543791 | 0.83 | KMT2A (0.37) | — | |
| SCHEMBL28786462 | 0.82 | CARM1 (0.37) | SLC6A2SLC6A4ABL1 | |
| SCHEMBL6543598 | 0.82 | ESRRA (0.50) | ESRRATHRBTHRA | |
| SCHEMBL27782470 | 0.82 | HPGD (0.39) | — | |
| SCHEMBL15930785 | 0.81 | ABL1 (0.35) | ESRRAABL1 | |
| SCHEMBL6544813 | 0.81 | ALDH1A1 (0.39) | ESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1022272-B1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | SANKYO CO (JP) | 2004-05-26 | — | — | EP | disclosed |
| US-6432993-B1 | BENZIMIDAZOLE OR IMIDAZO(4,5-B)PYRIDINE DERIVATES; IMMUNOMODULATORS; ALDOSE REDUCTASE AND LIPOXYGENASE INHIBITORS; DIABETES; PREVENTS LIPID PEROXIDATION; ANTILIPEMIC, HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1022272-A1 | SUBSTITUTED FUSED HETEROCYCLIC COMPOUNDS | Sankyo Company Limited (JP) | 2000-07-26 | — | — | EP | disclosed |