Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.50 |
| ▸ | NPC1 | O15118 | 9/20 | 0.50 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6545285 | 0.98 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53KDM4ENPC1RAB9A | |
| SCHEMBL19167337 | 0.82 | TP53 (0.39) | SMN1; SMN2TP53KDM4ENPC1RAB9A | |
| SCHEMBL13050330 | 0.81 | PDE10A (0.39) | SMN1; SMN2TP53KDM4ENPC1RAB9A | |
| SCHEMBL13050352 | 0.81 | TP53 (0.38) | SMN1; SMN2TP53KDM4ENPC1RAB9A | |
| SCHEMBL13050338 | 0.81 | TP53 (0.38) | SMN1; SMN2TP53KDM4ENPC1RAB9A | |
| SCHEMBL19497542 | 0.78 | MCHR1 (0.44) | SMN1; SMN2TP53KDM4E | |
| SCHEMBL13050350 | 0.78 | TLR9 (0.46) | SMN1; SMN2TP53KDM4ENPC1RAB9A | |
| SCHEMBL21100921 | 0.78 | TP53 (0.36) | SMN1; SMN2TP53KDM4ENPC1RAB9A | |
| SCHEMBL13050260 | 0.77 | NPC1 (0.53) | SMN1; SMN2TP53KDM4ENPC1RAB9A | |
| SCHEMBL434154 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2TP53KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040142961-A1 | Utilization of substituted imidazo[1,2-a]-pyridine compounds in pharmaceutical formulations | GRUENENTHAL GMBH (DE) | 2004-07-22 | — | — | US | claimed |
| EP-1372647-A2 | USE OF SUBSTITUTED IMIDAZO 1,2-A]-PYRIDINE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2004-01-02 | — | — | EP | claimed |
| WO-2002080914-A2 | USE OF SUBSTITUTED IMIDAZO[1,2-A]-PYRIDINE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2002-10-17 | — | — | WO | claimed |
| US-9540323-B2 | 7-hydroxy-indolinyl antagonists of P2Y1 receptor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150322069-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | FMR LLC | 2015-11-12 | — | — | US | disclosed |
| US-20150259286-A1 | 7-HYDROXY-INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR | BRISTOL-MYERS SQUIBB COMPANY | 2015-09-17 | — | — | US | disclosed |
| US-8946222-B2 | Phenoxymethyl heterocyclic compounds | FORUM PHARMACEUTICALS INC. (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140080756-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5]NONANE DERIVATIVES | PFIZER INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-20130143888-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | ENVIVO PHAMACEUTICALS, INC. (US) | 2013-06-06 | — | — | US | disclosed |
| CN-103012400-A | Novel synthesis method of pyridino-imidazole compound | UNIV SOOCHOW | 2013-04-03 | — | — | CN | disclosed |
| US-8343973-B2 | Phenoxymethyl heterocyclic compounds | ENVIVO PHARMACEUTICALS, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343973-B2 | Phenoxymethyl heterocyclic compounds | ENVIVO PHARMACEUTICALS, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | PFIZER INC. | 2011-09-22 | — | — | US | disclosed |
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | PFIZER INC. | 2011-09-22 | — | — | US | disclosed |
| US-20100292238-A1 | Phenoxymethyl Heterocyclic Compounds | FMR LLC | 2010-11-18 | — | — | US | disclosed |
| US-20100292238-A1 | Phenoxymethyl Heterocyclic Compounds | FMR LLC | 2010-11-18 | — | — | US | disclosed |
| US-20040142961-A1 | Utilization of substituted imidazo[1,2-a]-pyridine compounds in pharmaceutical formulations | GRUENENTHAL GMBH (DE) | 2004-07-22 | — | — | US | disclosed |
| EP-1372647-A2 | USE OF SUBSTITUTED IMIDAZO 1,2-A]-PYRIDINE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002080914-A2 | USE OF SUBSTITUTED IMIDAZO[1,2-A]-PYRIDINE COMPOUNDS AS MEDICAMENTS | Grünenthal GmbH (DE) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322069-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | PDE3A, PDE2A, PDE5A | SMN1; SMN2 331/4885TP53 4831/4885KDM4E 559/4885 |
| US-20040142961-A1 | Utilization of substituted imidazo[1,2-a]-pyridine compounds in pharmaceutical formulations | QDPR, PTGIS, DPYD | SMN1; SMN2 1400/4885TP53 2791/4885KDM4E 2101/4885 |
| US-20130143888-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | PDE3A, PDE2A, PDE5A | SMN1; SMN2 331/4885TP53 4831/4885KDM4E 559/4885 |
| US-20140080756-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5]NONANE DERIVATIVES | GIPR, GLP1R, GHSR | SMN1; SMN2 1617/4885TP53 3323/4885KDM4E 2805/4885 |
| US-20100292238-A1 | Phenoxymethyl Heterocyclic Compounds | PDE3A, PDE2A, PDE5A | SMN1; SMN2 331/4885TP53 4831/4885KDM4E 559/4885 |
| US-20150259286-A1 | 7-HYDROXY-INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR | P2RY1, P2RY11, P2RY2 | SMN1; SMN2 4735/4885TP53 4689/4885KDM4E 3921/4885 |
| US-20110230461-A1 | 2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES | GIPR, GLP1R, GHSR | SMN1; SMN2 1839/4885TP53 3083/4885KDM4E 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.